Fundamentals of Epigenetics
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12 chapters167 source pages
3 hoursestimated total reading
120 quiz questionsplus two cumulative exams

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01Chapter 1 · pp. 6–16Epigenetics, Traits, and Multigenerational Inheritance 10 min • 10 source-page views
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Traits, environment, and the inheritance questionp. 6A careful vocabulary for multigenerational effectsp. 11Mechanisms and interacting carriersp. 12An evidence ladder for inheritance claimsp. 12Sources Used in This Chapterp. 16
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02Chapter 2 · pp. 17–25DNA Structure and Nuclear Organization 12 min • 9 source-page views
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Nuclear and DNA architecturep. 17Epigenetic interpretation of DNA packagingp. 22
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03Chapter 3 · pp. 28–41DNA Replication and Epigenetic Continuity 14 min • 13 source-page views
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Replication machinery and sequence fidelityp. 28Chromatin restoration and regulatory continuityp. 32Replication within an interacting epigenetic networkp. 38Sources Used in This Chapterp. 41
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04Chapter 4 · pp. 42–56Chromatin Condensation and Histone Regulation 18 min • 14 source-page views
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Condensation as a regulatory systemp. 42Mechanistic extension and chapter reviewp. 47Histone methylation, LSD1, and cell identityp. 53Sources Used in This Chapterp. 56
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05Chapter 5 · pp. 57–72Transcription and RNA Processing 18 min • 15 source-page views
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From DNA to a processed RNA messagep. 57Transcription machinery and molecular logicp. 62RNA processing and expression controlp. 65Prokaryotic and eukaryotic transcription systemsp. 68Splicing as RNA-guided catalysisp. 69Sources Used in This Chapterp. 72
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06Chapter 6 · pp. 73–83Gene Regulation and the Epigenome 8 min • 10 source-page views
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The layered epigenomep. 73The mechanism set used in contemporary epigenetic analysisp. 79Environment, association, and causal interpretationp. 80Sources Used in This Chapterp. 83
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07Chapter 7 · pp. 83–96The Lick That Changed Everything 10 min • 12 source-page views
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Case Studyp. 86Interpreting what the case demonstratesp. 93Limits of extrapolationp. 93Sources Used in This Chapterp. 96
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08Chapter 8 · pp. 96–108Translation and Protein Control 10 min • 12 source-page views
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The translation systemp. 98Spatial and post-translational controlp. 102From a trait question to a proteinp. 105Sources Used in This Chapterp. 108
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09Chapter 9 · pp. 108–128Non-Coding RNAs and Gene Regulation 24 min • 19 source-page views
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The functional non-coding transcriptomep. 111Housekeeping and regulatory non-coding RNAsp. 125Additional small-RNA silencing systemsp. 125Long non-coding RNA and chromosome-scale regulationp. 125Sources Used in This Chapterp. 128
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10Chapter 10 · pp. 129–142Immunogenetics and Epigenome Editing 16 min • 13 source-page views
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Immunogenetics, receptor diversity, and editingp. 129Immune-system organization from the supplied lecturep. 139Sources Used in This Chapterp. 142
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11Chapter 11 · pp. 142–155Bioinformatics, AI, and Epigenetic Sequence Analysis 11 min • 13 source-page views
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Bioinformatics foundationsp. 144The data landscapep. 151Deep-learning architectures in the supplied reviewp. 152Challenges and recommendationsp. 152Sources Used in This Chapterp. 155
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12Chapter 12 · pp. 155–167Inborn Errors of Metabolism as a Molecular Capstone 12 min • 12 source-page views
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Metabolic pathway logic and disordersp. 157The supplied MCAD casep. 164Genetic disease and epigenetic regulation are not synonymsp. 164Sources Used in This Chapterp. 167
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Cumulative assessment

Exam 1

Chapters 1–7 · 25 questions by default

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Cumulative assessment

Exam 2

Chapters 8–12 · 25 questions by default

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